Journal of Bionic Memory

CRP-lymphocyte ratio as a novel marker of treatment response to hyperthyroidism with radioactive Iodine 131

2023-08-16T17:57:41+00:00

Aim: To compare CRP/lymphocyte ratio (CLR), a new inflammatory marker, before and after treatment of hyperthyroidism with Radioactive iodine 131 (RAI 131).

Methods: Patients who received RAI 131 treatment for hyperthyroidism in the Department of Nuclear Medicine between January 2020 and May 2023 were included in this retrospective study. Age, gender, WBC, hemoglobin neutrophil, platelet, glucose, AST, ALT and CLR values were compared before and within 1 year of treatment.

Results: There were 59 patients in the current study. 38 were women (64.4%) and 21 were men (33.3%). The mean age was 56.3±15.4 years. There was no statistically significant difference between before and after treatment values of WBC, hemoglobin, neutrophil, platelet, glucose, ALT and AST. However, CLR before treatment (1.74±2.34) was higher than after treatment (1±1.72) and the difference was statistically significant (p=0.048).

Conclusions: CLR, an inflammatory marker, decreased in patients receiving RAI 131 treatment due to hyperthyroidism after treatment. This supports that the presence of an inflammatory burden play an important role in thyroid pathologies. We think that this marker is a simple and useful marker that can be used to monitor the response of CLR to treatment in patients receiving RAI 131 therapy for hyperthyroidism.

Investigation of the histopathological differences of radial artery used for coronary bypass surgery by electron microscopy in two different age groups

2023-08-19T17:08:02+00:00

Aim: To investigate by electron microscopy whether there are any histopathological differences between the samples collected from the radial arteries used as grafts in the coronary bypass surgeries in two different age groups.

Methods: Forty patients whose radial artery grafts were prepared for myocardial revascularization purposes were included in this study. The patients were divided into two groups of twenty each: patients over and under 55. All patients included in the study were evaluated preoperatively for the arterial circulation of the hand from which the radial artery graft would be harvested. The radial artery was dissected as a pedicle together with the surrounding venous structures by means of low-voltage electrocautery. It was left in its original anatomic site until the harvesting of the sample. The harvested samples were examined using a transmission electron microscope, and their photos were taken.

Results: We found that the preoperative and intraoperative variables in both age groups were statistically similar except for age, and that the vessels in both groups were histologically normal, with minimal pathological changes.

Conclusion: We concluded that radial artery is a graft that can be used in suitable cases in coronary bypass surgery with no age restrictions.

Antegrade cerebral perfusion in thoracic aortic surgery: A single surgeon experience

2023-08-30T16:47:52+00:00

Aim: To present the experiences and outcomes in patients who underwent thoracic aortic surgery due to aortic aneurysm and/or dissection and in whom unilateral or bilateral antegrade cerebral perfusion was performed.

Methods: A total of 51 patients who underwent unilateral or bilateral antegrade cerebral perfusion during thoracic aortic surgery performed due to aortic aneurysm and/or acute type A aortic dissection were included in the study. Patients’ demographic data such as age and gender, comorbidity, diagnosis, type of procedure, type and duration of cerebral perfusion, temperature of hypothermia, and perioperative outcomes were recorded and retrospectively reviewed.

Results: Of all patients, 63.7% were male and 35.3% were female. The mean age of the patients was 55.1±12.0 years. Bilateral antegrade cerebral perfusion was performed in 47.1% and unilateral antegrade cerebral perfusion in 52.9% of the patients. The mean duration of antegrade cerebral perfusion was 60.2±26.6 minutes in patients with bilateral antegrade cerebral perfusion and 33.5±25.9 minutes in patients with unilateral antegrade cerebral perfusion. Mortality occurred in three patients, while one patient developed a major cerebrovascular event.

Conclusion: The present analysis revealed that antegrade cerebral perfusion performed during thoracic aortic surgery was associated with favorable perioperative outcomes.